Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 6/20 | 0.58 |
| ▸ | IL1B | P01584 | 3/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949344 | 0.91 | CASP1 (0.60) | CASP1IL1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL949978 | 0.88 | CASP1 (0.69) | CASP1IL1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL949353 | 0.84 | CASP1 (0.62) | CASP1IL1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL949718 | 0.83 | ELANE (0.48) | CASP1IL1BRAB9ANPC1 | |
| SCHEMBL951246 | 0.83 | CASP1 (0.54) | CASP1IL1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8647023 | 0.83 | CASP1 (0.60) | CASP1IL1BCNR2RAB9ANPC1 | |
| SCHEMBL950078 | 0.81 | CASP1 (0.54) | CASP1IL1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL952175 | 0.81 | CASP1 (0.73) | CASP1IL1BCNR2RAB9ANPC1 | |
| SCHEMBL8763059 | 0.80 | CASP1 (0.57) | CASP1IL1BCNR2RAB9ANPC1 | |
| SCHEMBL2800038 | 0.79 | CASP1 (0.66) | CASP1IL1BRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110015371-A1 | Inhibitors of interleukin-1 beta converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015371-A1 | Inhibitors of interleukin-1 beta converting enzyme | IL1B, IL1A, IL1R1 | CASP1 5/4885IL1B 1/4885CNR2 3663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.