Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750729 | 0.82 | HMGCR (0.58) | HMGCRTGFBR1HSP90AA1HSP90AB1GLA | |
| SCHEMBL9750874 | 0.79 | HMGCR (0.41) | HMGCRTGFBR1TGFBR2MAPK13MAPK12 | |
| SCHEMBL9521499 | 0.76 | HMGCR (0.62) | HMGCRRIPK2GLAPOLB | |
| SCHEMBL9518598 | 0.76 | HMGCR (0.56) | HMGCRTGFBR1CYP11B2CYP11B1RIPK2 | |
| SCHEMBL9750938 | 0.74 | HMGCR (0.51) | HMGCR | |
| SCHEMBL9518373 | 0.73 | HMGCR (0.58) | HMGCRRIPK2GLAPOLBEGFR | |
| SCHEMBL9518298 | 0.70 | HMGCR (0.59) | HMGCRRIPK2GLAPOLBEGFR | |
| SCHEMBL9518290 | 0.70 | HMGCR (0.59) | HMGCRRIPK2GLAPOLBEGFR | |
| SCHEMBL10455380 | 0.69 | HMGCR (0.45) | HMGCR | |
| SCHEMBL9732188 | 0.68 | PKM (0.37) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |