Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752923 | 0.81 | HTR2A (0.34) | ATMHTR2A | |
| SCHEMBL15859481 | 0.79 | CA1 (0.32) | CA1CA2 | |
| SCHEMBL7017926 | 0.74 | HTR2A (0.38) | HTR2ACYP3A4 | |
| SCHEMBL11297089 | 0.73 | HTR2A (0.35) | ATMHTR2ACA1CA2 | |
| SCHEMBL7214849 | 0.73 | HTR2A (0.40) | HTR2ACYP3A4 | |
| SCHEMBL21158160 | 0.71 | HTR2A (0.39) | HTR2ACYP3A4 | |
| Acetonitrile SCHEMBL28222988 | 0.70 | CYP2D6 (0.31) | ATMHTR2AALDH1A1MAPT | |
| SCHEMBL2528767 | 0.69 | HTR2A (0.38) | HTR2ACYP3A4ALDH1A1MAPT | |
| SCHEMBL6246911 | 0.69 | HTR2A (0.38) | HTR2ACYP3A4 | |
| SCHEMBL10654456 | 0.69 | HTR2A (0.38) | HTR2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102245562-B | Process for the synthesis of amino-methyltetralin derivatives | HOFFMANN LA ROCHE | 2014-08-13 | — | — | CN | disclosed |
| CN-101119965-B | Tetralin and indane derivatives and uses thereof | HOFFMANN LA ROCHE | 2012-09-26 | — | — | CN | disclosed |
| CN-102245562-A | Process for the synthesis of amino-methyltetralin derivatives | HOFFMANN LA ROCHE | 2011-11-16 | — | — | CN | disclosed |
| CN-101119965-A | Tetralin and indane derivatives and uses thereof | ROCHE PALO ALTO LLC (CH) | 2008-02-06 | — | — | CN | disclosed |
| EP-0325963-B1 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES AND -INDANES | ABBOTT LABORATORIES (US) | 1993-09-22 | — | — | EP | disclosed |
| US-5140040-A | Alpha-2-adrenergic receptor antagonist; glaucoma; congestive heart failure; hypotensive agents; headaches; metabolic disorders (diabetes, obesity) | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| US-5128362-A | Antidepressant, antiglaucoma | ABBOTT LABORATORIES (US) | 1992-07-07 | — | — | US | disclosed |
| US-5086074-A | Selective adrenergic receptor antagonists | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0395734-A4 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES | — | 1991-01-02 | — | — | EP | disclosed |
| EP-0395734-A1 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES | ABBOTT LABORATORIES (US) | 1990-11-07 | — | — | EP | disclosed |
| EP-0325963-A1 | 1-Aminomethyl-1,2,3,4-tetrahydronaphthalenes and -indanes | ABBOTT LABORATORIES (US) | 1989-08-02 | — | — | EP | disclosed |
| WO-1989006645-A1 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES | ABBOTT LABORATORIES (US) | 1989-07-27 | — | — | WO | disclosed |
| US-4764635-A | Aromatization process | ETHYL CORPORATION (US) | 1988-08-16 | — | — | US | disclosed |
| US-4764635-A | Aromatization process | ETHYL CORPORATION (US) | 1988-08-16 | — | — | US | disclosed |
| US-4762943-A | Aromatization process | ETHYL CORPORATION (US) | 1988-08-09 | — | — | US | disclosed |
| US-4762943-A | Aromatization process | ETHYL CORPORATION (US) | 1988-08-09 | — | — | US | disclosed |
| EP-0256849-A1 | Aromatization process | ETHYL CORPORATION (US) | 1988-02-24 | — | — | EP | disclosed |
| EP-0256849-A1 | Aromatization process | ETHYL CORPORATION (US) | 1988-02-24 | — | — | EP | disclosed |
| EP-0254422-A1 | Aromatization process | ETHYL CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |