Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.43 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.43 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522281 | 0.87 | CTSD (0.52) | CTSDLMNAMAPTALDH1A1NPSR1 | |
| SCHEMBL8268180 | 0.74 | KDM4E (0.67) | LMNAMAPTALDH1A1KDM4ETSHR | |
| SCHEMBL9522731 | 0.74 | LMNA (0.58) | CTSDLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL9522924 | 0.73 | CTSD (0.41) | CTSDLMNAKDM4EGUSB | |
| SCHEMBL27039669 | 0.71 | CCR1 (0.47) | LMNAMAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL4288066 | 0.71 | KDM4E (0.65) | LMNAALDH1A1PTGDR2KDM4E | |
| SCHEMBL4089473 | 0.70 | MAPT (0.63) | LMNAMAPTALDH1A1NPSR1PTGDR2 | |
| SCHEMBL9524921 | 0.70 | LMNA (0.53) | CTSDLMNAKDM4ECXCR3GUSB | |
| SCHEMBL1852575 | 0.70 | MAPT (0.48) | CTSDLMNAMAPTALDH1A1NPSR1 | |
| SCHEMBL569988 | 0.70 | KDM4E (0.70) | LMNAMAPTALDH1A1PTGDR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129409-B1 | Thiazolo - and thiazinobenzimidazoles | WYETH JOHN & BROTHER LTD (GB) | 1993-10-27 | — | — | EP | disclosed |
| US-4794123-A | Thiazolo- and thiazino- benzimidazoles and their use as anti-ulcer agents | JOHN WYETH & BROTHER LIMITED (GB) | 1988-12-27 | — | — | US | disclosed |
| US-4786636-A | ANTISECRETARY | JOHN WYETH & BROTHER LIMITED (GB) | 1988-11-22 | — | — | US | disclosed |
| US-4725605-A | Thiazolo- and thiazino-benzimidazoles, and their use as anti-ulcer/hypersecretion agents | JOHN WYETH & BROTHER LIMITED (GB) | 1988-02-16 | — | — | US | disclosed |
| EP-0129409-A2 | Thiazolo - and thiazinobenzimidazoles | JOHN WYETH & BROTHER LIMITED (GB) | 1984-12-27 | — | — | EP | disclosed |