Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10398492 | 0.83 | MAPT (0.68) | KMT2APLK1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL9523014 | 0.82 | S1PR4 (0.69) | KMT2AL3MBTL1S1PR4KDM4ESMN1; SMN2 | |
| SCHEMBL9522743 | 0.81 | S1PR4 (0.58) | KMT2AL3MBTL1S1PR4KDM4EALDH1A1 | |
| SCHEMBL4138460 | 0.80 | POLB (0.67) | KMT2AS1PR4KDM4ESMN1; SMN2POLB | |
| Ameltolide SCHEMBL635392 | 0.79 | S1PR4 (0.56) | KMT2AL3MBTL1S1PR4KDM4ESMN1; SMN2 | |
| SCHEMBL2307872 | 0.79 | S1PR4 (0.56) | KMT2AL3MBTL1S1PR4KDM4EALDH1A1 | |
| SCHEMBL1815922 | 0.79 | KDM4E (0.77) | KMT2AS1PR4KDM4ESMN1; SMN2POLB | |
| SCHEMBL9522953 | 0.79 | S1PR4 (0.56) | KMT2AL3MBTL1S1PR4KDM4ESMN1; SMN2 | |
| SCHEMBL11123393 | 0.79 | RXFP1 (0.59) | KMT2AS1PR4KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL9523578 | 0.78 | S1PR4 (0.55) | KMT2AL3MBTL1S1PR4KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279633-B1 | ANTICONVULSANT AGENTS | ELI LILLY AND COMPANY (US) | 1993-04-07 | — | — | EP | disclosed |
| US-4981866-A | BENZAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1991-01-01 | — | — | US | disclosed |
| US-4939163-A | 4-substituted benzamide derivatives | ELI LILLY AND COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| US-4835181-A | Anticonvulsant agents using cyano dimethylphenyl benzamides | ELI LILLY AND COMPANY (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0279633-A2 | Anticonvulsant agents | ELI LILLY AND COMPANY (US) | 1988-08-24 | — | — | EP | disclosed |