Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.58 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27983640 | 0.88 | KDM4E (0.60) | POLBHPGDKMT2ALMNAKDM4E | |
| SCHEMBL21590177 | 0.88 | LCK (0.68) | POLBHPGDKMT2ALMNAMAPT | |
| SCHEMBL11665956 | 0.88 | KDM4E (0.78) | POLBHPGDKMT2ALMNAKDM4E | |
| SCHEMBL9523014 | 0.86 | S1PR4 (0.69) | POLBHPGDKMT2AKDM4ES1PR4 | |
| SCHEMBL27872677 | 0.86 | ALDH1A1 (0.68) | POLBHPGDKMT2ALMNAKDM4E | |
| SCHEMBL15775601 | 0.85 | KDM4E (0.61) | POLBHPGDKMT2ALMNAKDM4E | |
| SCHEMBL9522743 | 0.85 | S1PR4 (0.58) | POLBHPGDKMT2AKDM4ES1PR4 | |
| SCHEMBL27645790 | 0.85 | LCK (0.66) | POLBHPGDKMT2ALMNAKCNK3 | |
| SCHEMBL2307872 | 0.83 | S1PR4 (0.56) | POLBHPGDKMT2ALMNAKDM4E | |
| Ameltolide SCHEMBL635392 | 0.83 | S1PR4 (0.56) | POLBHPGDKMT2ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303291-A1 | ROR GAMMA (ROR ) MODULATORS | Lead Pharma Holding B.V. (NL) | 2018-04-11 | — | — | EP | claimed |
| WO-2016193452-A1 | ROR GAMMA (RORγ) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-12-08 | — | — | WO | claimed |
| US-20090105211-A1 | INHIBITORS OF HEDGEHOG PATHWAY | EXELIXIS, INC. (US) | 2009-04-23 | — | — | US | claimed |
| US-20250326709-A1 | THE MICROWAVE-ASSISTED CATALYTIC AMIDATION OF ORGANIC AMINES WITH CARBOXYLIC ACIDS | PURDUE RESEARCH FOUNDATION (US) | 2025-10-23 | — | — | US | disclosed |
| WO-2022133594-A1 | METHODS FOR HYDROAMINOALKYLATION OF OLEFINS AND GROUP 4 METAL COMPLEXES USEFUL IN SUCH METHODS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2022-06-30 | — | — | WO | disclosed |
| CN-109912599-A | Chemical entities, composition and method | 英特利凯恩有限责任公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-106188059-B | Certain chemical entities, composition and method | 英特利凯恩有限责任公司 | 2019-02-01 | — | — | CN | disclosed |
| CN-104447727-A | Substituted aminopyrimidine compound as well as use method and application thereof | GUANGDONG HEC PHARMACEUTICAL | 2015-03-25 | — | — | CN | disclosed |
| EP-2527330-A1 | Inhibitors of the hedgehog pathway | Exelixis, Inc. (US) | 2012-11-28 | — | — | EP | disclosed |
| US-7589223-B2 | Polymerization catalysts, preparation of polyolefins, organotransition metal compounds and ligands | BASELL POLYOLEFINE GMBH (DE) | 2009-09-15 | — | — | US | disclosed |
| US-7589223-B2 | Polymerization catalysts, preparation of polyolefins, organotransition metal compounds and ligands | BASELL POLYOLEFINE GMBH (DE) | 2009-09-15 | — | — | US | disclosed |
| US-7589223-B2 | Polymerization catalysts, preparation of polyolefins, organotransition metal compounds and ligands | BASELL POLYOLEFINE GMBH (DE) | 2009-09-15 | — | — | US | disclosed |
| EP-1664132-B1 | POLYMERIZATION CATALYSTS, PREPARATION OF POLYOLEFINS, ORGANOTRANSITION METAL COMPOUNDS AND LIGANDS | BASELL POLYOLEFINE GMBH (DE) | 2008-05-07 | — | — | EP | disclosed |
| EP-1664132-B1 | POLYMERIZATION CATALYSTS, PREPARATION OF POLYOLEFINS, ORGANOTRANSITION METAL COMPOUNDS AND LIGANDS | BASELL POLYOLEFINE GMBH (DE) | 2008-05-07 | — | — | EP | disclosed |
| US-20070004884-A1 | Polymerization catalysts, preparation of polyolefins, organotransition metal compounds and ligands | LYONDELL CHEMICAL TECHNOLOGY, L.P. | 2007-01-04 | — | — | US | disclosed |
| US-20070004884-A1 | Polymerization catalysts, preparation of polyolefins, organotransition metal compounds and ligands | LYONDELL CHEMICAL TECHNOLOGY, L.P. | 2007-01-04 | — | — | US | disclosed |
| US-20070004884-A1 | Polymerization catalysts, preparation of polyolefins, organotransition metal compounds and ligands | LYONDELL CHEMICAL TECHNOLOGY, L.P. | 2007-01-04 | — | — | US | disclosed |
| EP-1664132-A1 | POLYMERIZATION CATALYSTS, PREPARATION OF POLYOLEFINS, ORGANOTRANSITION METAL COMPOUNDS AND LIGANDS | Basell Polyolefine GmbH (DE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005030813-A1 | POLYMERIZATION CATALYSTS, PREPARATION OF POLYOLEFINS, ORGANOTRANSITION METAL COMPOUNDS AND LIGANDS | BASELL POLYOLEFINE GMBH (DE) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105211-A1 | INHIBITORS OF HEDGEHOG PATHWAY | SHH, GLI1, SMO | POLB 4439/4885HPGD 3021/4885KMT2A 1508/4885 |
| US-20250326709-A1 | THE MICROWAVE-ASSISTED CATALYTIC AMIDATION OF ORGANIC AMINES WITH CARBOXYLIC ACIDS | NAAA, OAT, PAM | POLB 180/4885HPGD 800/4885KMT2A 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.