⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29178045 | 0.65 | — | — | |
| SCHEMBL10650634 | 0.65 | — | — | |
| SCHEMBL11021945 | 0.64 | — | — | |
| SCHEMBL9523235 | 0.63 | — | — | |
| SCHEMBL10883101 | 0.62 | — | — | |
| SCHEMBL10501834 | 0.61 | — | — | |
| Trichlormethine SCHEMBL8224 | 0.58 | LMNA (0.91) | — | |
| SCHEMBL9295642 | 0.56 | — | — | |
| Trichlormethine SCHEMBL1820371 | 0.55 | LMNA (0.83) | — | |
| Trichlormethine SCHEMBL338967 | 0.55 | LMNA (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0078167-B1 | NEW N-NITROSO-N-(BETA-CHLORO-ETHYL)-CARBAMOYL PEPTIDES | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1988-02-03 | — | — | EP | claimed |
| EP-0078167-A1 | New N-nitroso-N-(beta-chloro-ethyl)-carbamoyl peptides | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1983-05-04 | — | — | EP | claimed |
| EP-0533692-A1 | MITOMYCIN DERIVATIVES HAVING REDUCED BONE MARROW TOXICITY, PROCESSES FOR THEIR PREPARATION, AND THE USES THEREOF | GEORGETOWN UNIVERSITY (US) | 1993-03-31 | — | — | EP | disclosed |
| EP-0431008-A4 | MITOMYCIN DERIVATIVES HAVING REDUCED BONE MARROW TOXICITY, PROCESSES FOR THEIR PREPARATION, AND THE USES THEREOF | — | 1992-03-11 | — | — | EP | disclosed |
| US-5091523-A | Bactericides, antitumor agent | GEORGETOWN UNIVERSITY (US) | 1992-02-25 | — | — | US | disclosed |
| WO-1991016049-A1 | MITOMYCIN DERIVATIVES HAVING REDUCED BONE MARROW TOXICITY, PROCESSES FOR THEIR PREPARATION, AND THE USES THEREOF | GEORGETOWN UNIVERSITY (US) | 1991-10-31 | — | — | WO | disclosed |
| EP-0431008-A1 | MITOMYCIN DERIVATIVES HAVING REDUCED BONE MARROW TOXICITY, PROCESSES FOR THEIR PREPARATION, AND THE USES THEREOF | GEORGETOWN UNIVERSITY (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4950651-A | Leukemia; antitumer agents | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA R.T. (HU) | 1990-08-21 | — | — | US | disclosed |
| US-4950651-A | Leukemia; antitumer agents | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA R.T. (HU) | 1990-08-21 | — | — | US | disclosed |
| WO-1990001931-A1 | MITOMYCIN DERIVATIVES HAVING REDUCED BONE MARROW TOXICITY, PROCESSES FOR THEIR PREPARATION, AND THE USES THEREOF | GEORGETOWN UNIVERSITY (US) | 1990-03-08 | — | — | WO | disclosed |
| EP-0078167-B1 | NEW N-NITROSO-N-(BETA-CHLORO-ETHYL)-CARBAMOYL PEPTIDES | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1988-02-03 | — | — | EP | disclosed |
| US-4720543-A | 1a-7-substituted derivatives of mitomycin and uses thereof | GEORGETOWN UNIVERSITY (US) | 1988-01-19 | — | — | US | disclosed |
| EP-0222901-A1 | 1a-7-SUBSTITUTED DERIVATIVES OF MITOMYCIN AND USES THEREOF | GEORGETOWN UNIVERSITY (US) | 1987-05-27 | — | — | EP | disclosed |
| WO-1986007260-A1 | 1a-7-SUBSTITUTED DERIVATIVES OF MITOMYCIN AND USES THEREOF | GEORGETOWN UNIVERSITY (US) | 1986-12-18 | — | — | WO | disclosed |
| US-4615835-A | ANTITUMOR AGENTS, ANTICORCINOGENIC | STIFTUNG DEUTSCHES KREBSFORSCHUNGS ZENTRUM (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0078167-A1 | New N-nitroso-N-(beta-chloro-ethyl)-carbamoyl peptides | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1983-05-04 | — | — | EP | disclosed |
| EP-0078167-A1 | New N-nitroso-N-(beta-chloro-ethyl)-carbamoyl peptides | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1983-05-04 | — | — | EP | disclosed |
| US-4228086-A | CHEMICAL INTERMEDIATES FOR NITROSO UREAS | EISENBRAND GERHARD | 1980-10-14 | — | — | US | disclosed |
| US-4150146-A | ANTITUMOR, ANTICARCINOGENIC AGENTS | EISENBRAND GERHARD | 1979-04-17 | — | — | US | disclosed |