Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trichlormethine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HBB | P68871 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trichlormethine SCHEMBL8224 | 0.95 | LMNA (0.91) | LMNATSHRTP53HTTHBB | |
| Trichlormethine SCHEMBL1820371 | 0.91 | LMNA (0.83) | LMNATSHRTP53HTTHBB | |
| Trichlormethine SCHEMBL1651598 | 0.87 | LMNA (0.77) | LMNATSHRTP53HTTHBB | |
| SCHEMBL12552521 | 0.84 | LMNA (0.71) | LMNATSHRTP53HTTHBB | |
| Hydrochloric Acid SCHEMBL31671050 | 0.83 | LMNA (0.69) | LMNATSHRTP53HTTHBB | |
| Hydrochloric Acid SCHEMBL27869643 | 0.83 | LMNA (0.69) | LMNATSHRTP53HTTHBB | |
| Hydrochloric Acid SCHEMBL6780518 | 0.83 | LMNA (0.69) | LMNATSHRTP53HTTHBB | |
| Hydrochloric Acid SCHEMBL2771613 | 0.83 | LMNA (0.69) | LMNATSHRTP53HTTHBB | |
| SCHEMBL7039551 | 0.81 | LMNA (0.67) | LMNATSHRTP53HTTHBB | |
| SCHEMBL12552525 | 0.81 | LMNA (0.67) | LMNATSHRTP53HTTHBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119790166-A | Markers for early detection of colonic cell proliferative disorders | 福瑞诺姆控股公司 | 2025-04-08 | — | — | CN | claimed |
| CN-112855120-B | Automatic metering device for single well and two phases of oil field | 陕西延长石油（集团）有限责任公司 | 2025-03-18 | — | — | CN | claimed |
| CN-110057302-B | Underground safety-oriented full-automatic measuring device and measuring method | 南京工业职业技术学院 | 2024-08-27 | — | — | CN | claimed |
| CN-117384232-A | Primer synthesis method with high ammonolysis degree | 通用生物(安徽)股份有限公司 | 2024-01-12 | — | — | CN | claimed |
| CN-115710429-A | Hydrolysis-resistant alcoholysis-resistant reinforced nylon material and preparation method thereof | 青岛国恩科技股份有限公司 | 2023-02-24 | — | — | CN | claimed |
| CN-113477052-B | Aminoethylated piperazine, preparation method thereof, carbon dioxide absorbent and application thereof | 大连理工大学 | 2022-05-24 | — | — | CN | claimed |
| CN-109516919-B | Preparation method of tri (2-aminoethyl) amine | 安徽工业大学科技园有限公司 | 2021-12-14 | — | — | CN | claimed |
| CN-109438252-B | Synthesis process of tri (2-aminoethyl) amine | 安徽工业大学科技园有限公司 | 2021-12-14 | — | — | CN | claimed |
| CN-113477052-A | Aminoethylated piperazine, preparation method thereof, carbon dioxide absorbent and application thereof | 大连理工大学 | 2021-10-08 | — | — | CN | claimed |
| CN-108164428-B | Preparation method of tris (2-chloroethyl) amine hydrochloride | 山东泰和水处理科技股份有限公司 | 2021-06-18 | — | — | CN | claimed |
| US-20200131431-A1 | CHEMICAL ADDITIVES AND SURFACTANT COMBINATIONS FOR FAVORABLE WETTABILITY ALTERATION AND IMPROVED HYDROCARBON RECOVERY FACTORS | ALCHEMY SCIENCES INC (US) | 2020-04-30 | — | — | US | claimed |
| US-20190169342-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA, INC. | 2019-06-06 | — | — | US | claimed |
| US-20140044671-A1 | AMINE CONDENSATION POLYMERS AS PHOSPHATE SEQUESTRANTS | GENZYME CORPORATION (US) | 2014-02-13 | — | — | US | claimed |
| EP-2538947-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | Relypsa, Inc. (US) | 2013-01-02 | — | — | EP | claimed |
| WO-2011106545-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA, INC. (US) | 2011-09-01 | — | — | WO | claimed |
| US-20100254935-A1 | Amine condensation polymers as phosphate sequestrants | GENZYME CORPORATION (US) | 2010-10-07 | — | — | US | claimed |
| US-20080085259-A1 | Amine condensation polymers as phosphate sequestrants | GENZYME CORPORATION | 2008-04-10 | — | — | US | claimed |
| EP-0005094-B1 | PROCESS FOR THE PREPARATION OF TRIS-(POLYOXAALKYL)-AMINES | RHONE-POULENC INDUSTRIES (FR) | 1980-10-29 | — | — | EP | claimed |
| EP-0005090-B1 | PROCESS FOR THE PREPARATION OF TRIS(8-HYDROXY-3,6-DIOXA-OCTYL)-AMINE, AND THE COMPOUND OBTAINED BY THIS PROCESS | RHONE-POULENC INDUSTRIES (FR) | 1980-10-01 | — | — | EP | claimed |
| EP-0002147-B1 | PROCESS FOR THE PREPARATION OF TRIS(3-OXA-5-HYDROXY-PENTYL)AMINE | RHONE-POULENC INDUSTRIES (FR) | 1980-07-23 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140044671-A1 | AMINE CONDENSATION POLYMERS AS PHOSPHATE SEQUESTRANTS | PHPT1, CEPT1, PNMT | LMNA 3373/4885TSHR 3850/4885TP53 2727/4885 |
| US-20080085259-A1 | Amine condensation polymers as phosphate sequestrants | PHPT1, CEPT1, PNMT | LMNA 3373/4885TSHR 3850/4885TP53 2727/4885 |
| US-20100254935-A1 | Amine condensation polymers as phosphate sequestrants | PHPT1, CEPT1, PNMT | LMNA 3373/4885TSHR 3850/4885TP53 2727/4885 |
| US-20190169342-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | NR1H4, SLC10A2, ITCH | LMNA 4519/4885TSHR 3816/4885TP53 4319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.