Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 11/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.52 |
| ▸ | QPCT | Q16769 | 1/20 | 0.52 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.52 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.52 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524490 | 0.82 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL9707231 | 0.79 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL9525410 | 0.79 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL9525445 | 0.79 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL9663727 | 0.79 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| Hydrochloric Acid SCHEMBL9527151 | 0.78 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL9527191 | 0.76 | CYP19A1 (0.52) | CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL9662930 | 0.76 | CYP19A1 (0.54) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL9868315 | 0.75 | CYP19A1 (0.46) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL9664261 | 0.75 | KCNH2 (0.59) | CYP11B1CYP11B2CYP19A1CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |