SCHEMBL9524490

SCHEMBL9524490

c1ccc(Cn2nnc3ccc(Cn4ccnc4)cc32)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 11/20 0.60
CYP11B2 P19099 11/20 0.60
CYP19A1 P11511 5/20 0.60
CYP1A2 P05177 1/20 0.60
POLB P06746 1/20 0.60
CYP3A4 P08684 1/20 0.60
CYP2D6 P10635 1/20 0.60
MAPT P10636 1/20 0.60
TBXAS1 P24557 1/20 0.60
QPCT Q16769 1/20 0.60
CYP4Z1 Q86W10 1/20 0.60
QPCTL Q9NXS2 1/20 0.60
CYP17A1 P05093 1/20 0.55
GRM2 Q14416 2/20 0.54
SLC9A1 P19634 1/20 0.54
KDM4E B2RXH2 1/20 0.51
ALDH1A1 P00352 1/20 0.51
ADRA2C P18825 1/20 0.49
CYP2A6 P11509 1/20 0.48
CYP2B6 P20813 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9523481 0.82 CYP11B1 (0.52) CYP11B1CYP11B2CYP19A1CYP1A2POLB
SCHEMBL9525445 0.81 CYP11B1 (0.51) CYP11B1CYP11B2CYP19A1CYP1A2POLB
SCHEMBL9527239 0.81 SLC9A1 (0.49) CYP11B1CYP11B2CYP19A1TBXAS1SLC9A1
SCHEMBL9525410 0.79 CYP11B1 (0.51) CYP11B1CYP11B2CYP19A1TBXAS1CYP2A6
SCHEMBL9707231 0.79 CYP11B1 (0.51) CYP11B1CYP11B2CYP19A1TBXAS1ALDH1A1
Hydrochloric Acid SCHEMBL9527151 0.78 CYP11B1 (0.50) CYP11B1CYP11B2CYP19A1TBXAS1ALDH1A1
Benzylimidazole SCHEMBL414 0.78 CYP11B1 (1.00) CYP11B1CYP11B2CYP19A1CYP1A2POLB
SCHEMBL22063900 0.78 CYP11B1 (1.00) CYP11B1CYP11B2CYP19A1CYP1A2POLB
SCHEMBL9527191 0.76 CYP19A1 (0.52) CYP11B1CYP11B2CYP19A1TBXAS1ALDH1A1
Benzylimidazole SCHEMBL16237308 0.76 CYP11B1 (0.96) CYP11B1CYP11B2CYP19A1CYP1A2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0293978-B1 (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1993-09-15 EP disclosed
US-5039677-A Estrogen inhibitor JANSSEN PHARMACEUTICA N.V. (CA) 1991-08-13 US disclosed
US-4943574-A AROMATASE INHIBITORS, ESTROGEN DISORDERS JANSSEN PHARMACEUTICA N.V. (BE) 1990-07-24 US disclosed
EP-0293978-A2 (1H-azol-1-ylmethyl)substituted benzotriazole derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1988-12-07 EP disclosed