Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.68 |
| ▸ | DRD4 | P21917 | 2/20 | 0.68 |
| ▸ | DRD3 | P35462 | 2/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.68 |
| ▸ | BCHE | P06276 | 2/20 | 0.63 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.61 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12040583 | 0.86 | SIGMAR1 (0.61) | SIGMAR1MAPTLMNAGAAKMT2A | |
| SCHEMBL8092627 | 0.83 | SIGMAR1 (0.60) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL8099595 | 0.83 | SIGMAR1 (0.68) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL9011908 | 0.82 | FFAR1 (0.60) | DRD2DRD4DRD3SIGMAR1MAPT | |
| SCHEMBL13979591 | 0.81 | S1PR1 (0.59) | SIGMAR1S1PR1S1PR3MAPTLMNA | |
| SCHEMBL8092974 | 0.81 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL7032991 | 0.81 | SIGMAR1 (0.56) | SIGMAR1MAPTLMNAGAAKMT2A | |
| SCHEMBL3621768 | 0.80 | SIGMAR1 (0.70) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL4248652 | 0.80 | NQO1 (0.67) | SIGMAR1MAPTLMNAKMT2ARAB9A | |
| SCHEMBL4254894 | 0.80 | SIGMAR1 (1.00) | DRD2DRD4DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | disclosed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | disclosed |