Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21835471 | 0.86 | CYP3A4 (0.44) | SLC6A2SLC6A4SLC6A3CYP2D6OPRM1 | |
| SCHEMBL11715846 | 0.82 | HTR2A (0.41) | SLC6A2SLC6A4SLC6A3HTR2AOPRM1 | |
| SCHEMBL7147295 | 0.79 | HTR2A (0.39) | SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL1036893 | 0.78 | HTR2A (0.38) | SLC6A2SLC6A4SLC6A3HTR2AOPRM1 | |
| SCHEMBL7008386 | 0.77 | OPRM1 (0.38) | SLC6A2SLC6A4SLC6A3HTR2ACYP2D6 | |
| SCHEMBL27825135 | 0.77 | TSHR (0.39) | SLC6A2SLC6A4SLC6A3HTR2AOPRM1 | |
| SCHEMBL15271649 | 0.77 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL1961851 | 0.75 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3HTR2ACYP2D6 | |
| SCHEMBL6494298 | 0.75 | MAOA (0.43) | OPRM1MAOAMAOB | |
| SCHEMBL6494304 | 0.75 | MAOA (0.43) | OPRM1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | claimed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | claimed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | claimed |