Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5418012 | 0.70 | PTGS2 (0.57) | HPGDKMT2AMEN1TP53ALOX12 | |
| SCHEMBL9524003 | 0.66 | MAPT (0.58) | KMT2ATP53NPC1RAB9ALMNA | |
| SCHEMBL10902105 | 0.65 | CYP3A4 (0.66) | HPGDKMT2AMEN1RAB9AMAPT | |
| SCHEMBL11387427 | 0.65 | CYP1A2 (0.53) | KMT2ALMNASMN1; SMN2MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL5434406 | 0.65 | PTGS2 (0.53) | HPGDKMT2AMEN1TP53ALOX12 | |
| SCHEMBL1699007 | 0.65 | PTGS2 (0.43) | ALDH1A1PTGS2 | |
| SCHEMBL16044269 | 0.65 | PTGS2 (0.59) | HPGDSMN1; SMN2MAPTALDH1A1PTGS1 | |
| SCHEMBL2175491 | 0.65 | PTGS2 (0.43) | KMT2AMEN1LMNASMN1; SMN2MAPT | |
| SCHEMBL9375623 | 0.64 | — | — | |
| SCHEMBL16474715 | 0.64 | ACHE (0.48) | HPGDKMT2AMEN1TP53ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0261004-B1 | IMIDAZOLE DERIVATIVES AND THEIR SALTS, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-05-26 | — | — | EP | disclosed |
| US-5063229-A | Antiinflammatory agents | ROUSSEL ULCAF (FR) | 1991-11-05 | — | — | US | disclosed |
| US-4895866-A | Anti-inflammatory imidazole compounds | ROUSSEL UCLAF (FR) | 1990-01-23 | — | — | US | disclosed |
| US-4810828-A | ANTIARTHRITIC, PSORIASIS | ROUSSEL UCLAF (FR) | 1989-03-07 | — | — | US | disclosed |
| EP-0261004-A2 | Imidazole derivatives and their salts, process for their preparation, their use as medicines, and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-03-23 | — | — | EP | disclosed |