Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5418012 | 0.78 | PTGS2 (0.57) | MAPTLMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5415921 | 0.70 | PTGS2 (0.53) | MAPTLMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4960613 | 0.68 | P2RX7 (0.62) | MAPTALDH1A1CYP2A6KMT2A | |
| SCHEMBL4036684 | 0.68 | CCR1 (0.30) | — | |
| SCHEMBL5421693 | 0.67 | GABRA2 (0.49) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL11387397 | 0.67 | NR4A1 (0.57) | MAPTLMNARAB9ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL11377545 | 0.67 | SMN1; SMN2 (0.59) | MAPTLMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL24137386 | 0.66 | CYP11B1 (0.51) | ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL9524015 | 0.66 | HPGD (0.40) | MAPTLMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28536742 | 0.66 | MAPT (0.50) | MAPTLMNARAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0261004-B1 | IMIDAZOLE DERIVATIVES AND THEIR SALTS, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-05-26 | — | — | EP | disclosed |
| US-5063229-A | Antiinflammatory agents | ROUSSEL ULCAF (FR) | 1991-11-05 | — | — | US | disclosed |
| US-4895866-A | Anti-inflammatory imidazole compounds | ROUSSEL UCLAF (FR) | 1990-01-23 | — | — | US | disclosed |
| US-4810828-A | ANTIARTHRITIC, PSORIASIS | ROUSSEL UCLAF (FR) | 1989-03-07 | — | — | US | disclosed |
| EP-0261004-A2 | Imidazole derivatives and their salts, process for their preparation, their use as medicines, and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-03-23 | — | — | EP | disclosed |