Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.41 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9591517 | 0.90 | PDGFRB (0.53) | LEF1PDGFRBPDGFRAMMP13GAA | |
| SCHEMBL5087407 | 0.81 | LEF1 (0.55) | LEF1MMP13GAAMEN1KMT2A | |
| SCHEMBL6617416 | 0.81 | LEF1 (0.74) | LEF1PDGFRBPDGFRAMMP13GAA | |
| SCHEMBL9522383 | 0.79 | PDGFRB (0.61) | PDGFRBPDGFRAMEN1KMT2AKDM4E | |
| SCHEMBL3030225 | 0.77 | LEF1 (0.60) | LEF1MMP13MMP2KMT2AMAPT | |
| SCHEMBL7155166 | 0.77 | HRH4 (0.55) | PDGFRBPDGFRALGALS8LGALS3MEN1 | |
| SCHEMBL6619949 | 0.77 | LEF1 (0.81) | LEF1MMP13GAAMEN1KMT2A | |
| SCHEMBL3027522 | 0.77 | MMP13 (0.72) | LEF1MMP13GAAMMP2MEN1 | |
| SCHEMBL741209 | 0.77 | PDGFRB (0.58) | PDGFRBPDGFRALGALS8LGALS3MEN1 | |
| SCHEMBL13311254 | 0.76 | LEF1 (0.59) | LEF1MMP13GAAMMP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354583-B1 | DC-88A derivatives | KYOWA HAKKO KOGYO KK (JP) | 1993-11-03 | — | — | EP | disclosed |
| US-5248692-A | DC-89 derivatives as anti-tumor agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| US-5214065-A | Antitumor agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-05-25 | — | — | US | disclosed |
| US-5117006-A | DC-88A DERIVATIVES USEFUL AS ANTITUMOR AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| US-5084468-A | Antitumor agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-28 | — | — | US | disclosed |
| EP-0461603-A1 | DC-89 derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-18 | — | — | EP | disclosed |
| EP-0354583-A1 | DC-88A derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-02-14 | — | — | EP | disclosed |