Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 7/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CCND2 | P30279 | 2/20 | 0.36 |
| ▸ | CCND3 | P30281 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9791377 | 1.00 | GCGR (0.40) | GCGRCDK4CCND1CCND2CCND3 | |
| SCHEMBL9728453 | 0.80 | GCGR (0.40) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9698248 | 0.80 | GCGR (0.40) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9734648 | 0.80 | DPP4 (0.42) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9387195 | 0.80 | DPP4 (0.42) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9384186 | 0.80 | GCGR (0.38) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9735137 | 0.80 | GCGR (0.38) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9791331 | 0.78 | HMGCR (0.49) | ESR1HMGCRCHRM1TBXA2RPDE4A | |
| SCHEMBL8949683 | 0.78 | GCGR (0.53) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9791356 | 0.75 | GCGR (0.40) | GCGRESR1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391185-B1 | Substituted 1,8-naphthyridines | BAYER AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| US-5034399-A | Enzyme inhibitors, anticholesterol agents or antilipemic agents | BAYER AKTIENGESELLSCHAFT (DE) | 1991-07-23 | — | — | US | disclosed |
| EP-0391185-A1 | Substituted 1,8-naphthyridines | BAYER AG (DE) | 1990-10-10 | — | — | EP | disclosed |