Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 6/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524801 | 0.81 | ABCC9 (0.45) | ABCC9ABCB1SIRT2ABCC8KCNJ11 | |
| SCHEMBL9525755 | 0.78 | ABCC9 (0.40) | ABCC9ABCB1KDM4EABCC8KCNJ11 | |
| SCHEMBL8967989 | 0.78 | ABCC9 (0.43) | ABCC9ABCB1SIRT2KDM4E | |
| SCHEMBL8338287 | 0.78 | ABCC9 (0.43) | ABCC9ABCB1SIRT2KDM4E | |
| SCHEMBL9628037 | 0.78 | ABCB1 (0.38) | ABCC9ABCB1SIRT2KDM4EABCC8 | |
| SCHEMBL8795413 | 0.77 | TRPV1 (0.46) | CYP11B2NPC1MAPTSMN1; SMN2 | |
| SCHEMBL9377895 | 0.77 | CYP19A1 (0.36) | CYP11B2MAPTSMN1; SMN2 | |
| SCHEMBL8795861 | 0.77 | CYP19A1 (0.41) | ALDH1A1HPGDKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL8794702 | 0.75 | CYP19A1 (0.37) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9530024 | 0.75 | SIRT2 (0.47) | ABCC9ABCB1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| CN-1030582-A | 1-benzopyran derivatives | HOFFMANN LA ROCHE (CH) | 1989-01-25 | — | — | CN | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |