Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9377895 | 0.79 | CYP19A1 (0.36) | CYP19A1MAPTSMN1; SMN2CYP3A4TRPV1 | |
| SCHEMBL8795413 | 0.79 | TRPV1 (0.46) | CYP19A1MAPTSMN1; SMN2NAMPTCYP3A4 | |
| SCHEMBL9524573 | 0.75 | ABCC9 (0.42) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8795861 | 0.75 | CYP19A1 (0.41) | CYP19A1MAPTSMN1; SMN2CYP3A4TRPV1 | |
| SCHEMBL8795100 | 0.72 | CYP19A1 (0.36) | CYP19A1MAPTSMN1; SMN2CYP3A4TRPV1 | |
| SCHEMBL8795664 | 0.71 | NAMPT (0.37) | SMN1; SMN2NAMPTESPL1ALDH1A1 | |
| SCHEMBL9475076 | 0.67 | ALDH1A1 (0.41) | ESPL1ALDH1A1 | |
| SCHEMBL8793951 | 0.67 | PTGS2 (0.39) | NAMPTESPL1ALDH1A1 | |
| SCHEMBL15955551 | 0.66 | NAPRT (0.57) | NAMPTALDH1A1 | |
| SCHEMBL9475562 | 0.64 | ALDH1A1 (0.43) | CYP3A4ESPL1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634401-B1 | MDR reversal agents | AMERICAN CYANAMID CO (US) | 1997-08-13 | — | — | EP | claimed |
| EP-0586405-B1 | NOVEL 2H-BENZO[b]PYRANE DERIVATIVES SUBSTITUTED IN THE 4 POSITION BY ARYL OR N-HETEROARYL, PROCESS FOR PRODUCING THEM AND PREPARATIONS CONTAINING THE COMPOUNDS | BEIERSDORF LILLY GMBH (DE) | 1997-09-10 | — | — | EP | disclosed |
| EP-0586405-A1 | NOVEL 2H-BENZO b]PYRANE DERIVATIVES SUBSTITUTED IN THE 4 POSITION BY ARYL OR N-HETEROARYL, PROCESS FOR PRODUCING THEM AND PREPARATIONS CONTAINING THE COMPOUNDS. | BEIERSDORF LILLY GMBH (DE) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992020671-A1 | NOVEL 2H-BENZO[b]PYRANE DERIVATIVES SUBSTITUTED IN THE 4 POSITION BY ARYL OR N-HETEROARYL, PROCESS FOR PRODUCING THEM AND PREPARATIONS CONTAINING THE COMPOUNDS | BEIERSDORF-LILLY GMBH (DE) | 1992-11-26 | — | — | WO | disclosed |