SCHEMBL9524765

SCHEMBL9524765

Cn1nnc2ccc(C(O)c3ccsc3)cc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 5/20 0.44
CYP11B1 P15538 1/20 0.41
KEAP1 Q14145 4/20 0.38
SLC9A1 P19634 1/20 0.38
NPSR1 Q6W5P4 1/20 0.35
HCAR3 P49019 1/20 0.35
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
NSD2 O96028 1/20 0.33
ALDH1A1 P00352 1/20 0.32
NOTUM Q6P988 1/20 0.32
IDO1 P14902 1/20 0.32
TDO2 P48775 1/20 0.32
HPGD P15428 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9525014 0.80 KEAP1 (0.50) CYP19A1CYP11B1KEAP1SLC9A1HCAR3
SCHEMBL9026711 0.79 CYP19A1 (0.58) CYP19A1CYP11B1KEAP1SLC9A1HCAR3
SCHEMBL9523605 0.77 CYP19A1 (0.43) CYP19A1CYP11B1KEAP1SLC9A1HCAR3
SCHEMBL9524627 0.76 CYP19A1 (0.45) CYP19A1CYP11B1
SCHEMBL9524777 0.74 HCAR3 (0.51) KEAP1SLC9A1NPSR1HCAR3MEN1
SCHEMBL15341829 0.73 CYP19A1 (0.50) CYP19A1CYP11B1KEAP1SLC9A1NPSR1
SCHEMBL5104539 0.70 ALOX5 (0.42) L3MBTL1IDO1TDO2CYP3A4CYP2D6
SCHEMBL9524664 0.69 KEAP1 (0.52) KEAP1SLC9A1HCAR3MEN1KMT2A
SCHEMBL8884360 0.66 CYP19A1 (0.60) CYP19A1CYP11B1KEAP1SLC9A1HCAR3
SCHEMBL3192611 0.66 KEAP1 (0.53) CYP19A1CYP11B1KEAP1SLC9A1HCAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0293978-B1 (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1993-09-15 EP disclosed
US-5039677-A Estrogen inhibitor JANSSEN PHARMACEUTICA N.V. (CA) 1991-08-13 US disclosed
US-4943574-A AROMATASE INHIBITORS, ESTROGEN DISORDERS JANSSEN PHARMACEUTICA N.V. (BE) 1990-07-24 US disclosed
EP-0293978-A2 (1H-azol-1-ylmethyl)substituted benzotriazole derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1988-12-07 EP disclosed