Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 8/20 | 0.36 |
| ▸ | WRN | Q14191 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524424 | 0.84 | NPC1 (0.38) | KIF11WRNHDAC6HDAC1 | |
| SCHEMBL3045728 | 0.78 | RAB9A (0.42) | HDAC6HDAC1HSD17B2 | |
| SCHEMBL27961778 | 0.76 | KIF11 (0.52) | PRF1KIF11HSD17B2 | |
| SCHEMBL14705447 | 0.76 | KIF11 (0.52) | PRF1KIF11HSD17B2 | |
| SCHEMBL14705469 | 0.74 | KIF11 (0.50) | PRF1KIF11WRNMKNK1MKNK2 | |
| SCHEMBL25165734 | 0.73 | KIF11 (0.54) | PRF1KIF11HSD17B2 | |
| SCHEMBL27274253 | 0.72 | DAO (0.41) | — | |
| SCHEMBL332062 | 0.70 | CYP3A4 (0.37) | — | |
| SCHEMBL28473667 | 0.70 | KIF11 (0.68) | KIF11HDAC6BACE1HSD17B2 | |
| SCHEMBL160983 | 0.69 | CYP3A4 (0.50) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259972-B1 | HETEROCYCLIC PROPENE AMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | LILLY INDUSTRIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| US-4983619-A | Leukotriene antagonists | LILLY INDUSTRIES LIMITED (GB) | 1991-01-08 | — | — | US | disclosed |
| EP-0259972-A2 | Heterocyclic propene amide derivatives, processes for their preparation and their use as pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1988-03-16 | — | — | EP | disclosed |