Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10642767 | 0.88 | RIPK1 (0.43) | NPC1RAB9AHIF1AGRM5KMT2A | |
| SCHEMBL9524782 | 0.87 | GRM5 (0.47) | NPC1RAB9AHIF1AGRM5KMT2A | |
| SCHEMBL9523503 | 0.86 | KCNMA1 (0.50) | NPC1RAB9AHIF1AGRM5KMT2A | |
| SCHEMBL9527884 | 0.82 | POLB (0.45) | NPC1RAB9AHIF1AKMT2AMEN1 | |
| SCHEMBL9525679 | 0.81 | NPC1 (0.54) | NPC1RAB9AHIF1AGRM5KMT2A | |
| SCHEMBL9525753 | 0.77 | KCNMA1 (0.57) | NPC1RAB9AHIF1AGRM5KMT2A | |
| SCHEMBL9524579 | 0.77 | HIF1A (0.54) | NPC1RAB9AHIF1AKMT2AMEN1 | |
| SCHEMBL9524359 | 0.77 | MEN1 (0.49) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL9525648 | 0.76 | RIPK1 (0.47) | NPC1RAB9AHIF1AGRM5KMT2A | |
| SCHEMBL9525735 | 0.75 | EGLN1 (0.49) | NPC1RAB9AKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |