Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525440 | 0.86 | NPC1 (0.49) | KCNMA1GRM5NPC1RAB9AKMT2A | |
| SCHEMBL9524703 | 0.83 | GPR27 (0.46) | NPC1RAB9AKMT2AHIF1APKM | |
| SCHEMBL9525753 | 0.82 | KCNMA1 (0.57) | KCNMA1GRM5NPC1RAB9AKMT2A | |
| SCHEMBL9524782 | 0.82 | GRM5 (0.47) | KCNMA1GRM5NPC1RAB9AKMT2A | |
| SCHEMBL9525648 | 0.79 | RIPK1 (0.47) | GRM5NPC1RAB9AKMT2AHIF1A | |
| SCHEMBL10642767 | 0.78 | RIPK1 (0.43) | KCNMA1GRM5NPC1RAB9AKMT2A | |
| SCHEMBL9525679 | 0.76 | NPC1 (0.54) | GRM5NPC1RAB9AKMT2AGAA | |
| SCHEMBL9524970 | 0.75 | HSP90AA1 (0.47) | KMT2ATP53PKMMEN1SMN1; SMN2 | |
| SCHEMBL9527689 | 0.73 | NPC1 (0.46) | KCNMA1GRM5NPC1RAB9AKMT2A | |
| SCHEMBL9525699 | 0.73 | GRM5 (0.46) | GRM5NPC1RAB9AKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |