Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453149 | 0.83 | NFKB1 (0.46) | KDM4ACTSBCTSSCTSKMAPT | |
| SCHEMBL9530194 | 0.76 | NQO2 (0.47) | KDM4ACTSSCTSKNQO2MAPT | |
| SCHEMBL13903530 | 0.76 | KDM4E (0.64) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL29679010 | 0.74 | KDM4A (0.50) | KDM4AACACBCTSSCTSKNQO2 | |
| SCHEMBL28074205 | 0.74 | ACE (0.40) | CTSBCTSSCTSKNQO2 | |
| SCHEMBL27820408 | 0.73 | HDAC3 (0.45) | PPARAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL23843620 | 0.73 | PDK2 (0.60) | KDM4AACACBNQO2CNR2KDM4E | |
| SCHEMBL30301420 | 0.73 | HDAC3 (0.54) | KDM4ANQO2GABRB1GABRB2HDAC1 | |
| SCHEMBL27015167 | 0.73 | HDAC3 (0.54) | KDM4ANQO2GABRB1GABRB2HDAC1 | |
| SCHEMBL10431398 | 0.72 | CTSS (0.43) | KDM4ACTSSCTSKPPARAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365045-B1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1993-12-01 | — | — | EP | disclosed |
| EP-0365045-A1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1990-04-25 | — | — | EP | disclosed |