Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | POLR1A | O95602 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | SCN1A | P35498 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524590 | 0.87 | RAD52 (0.49) | KDM4EALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL9527401 | 0.83 | TSHR (0.51) | KDM4EALDH1A1SMN1; SMN2HPGDHTT | |
| SCHEMBL9524829 | 0.82 | HTT (0.56) | KDM4EALDH1A1HPGDCYP1A2POLR1A | |
| SCHEMBL9525682 | 0.81 | NAAA (0.52) | KDM4EALDH1A1SMN1; SMN2HPGDGAA | |
| SCHEMBL9525892 | 0.81 | NAAA (0.52) | KDM4EALDH1A1SMN1; SMN2HPGDGAA | |
| SCHEMBL9523732 | 0.78 | RAB9A (0.55) | ALDH1A1SMN1; SMN2LMNAGAAHTT | |
| SCHEMBL821644 | 0.76 | EGLN1 (0.62) | — | |
| SCHEMBL9527944 | 0.76 | NSD2 (0.50) | KDM4EALDH1A1GAAEGFRMAPT | |
| SCHEMBL31372088 | 0.76 | EGLN1 (0.62) | — | |
| SCHEMBL9524740 | 0.75 | USP2 (0.53) | KDM4EALDH1A1SMN1; SMN2HPGDPOLR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |