Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527509 | 0.85 | KMT2A (0.38) | KMT2AMEN1ATMCCKBRPLA2G10 | |
| SCHEMBL9526436 | 0.84 | PLA2G10 (0.43) | CCKBRPLA2G10PLA2G5 | |
| SCHEMBL10635209 | 0.84 | PLA2G10 (0.43) | CCKBRPLA2G10PLA2G5 | |
| SCHEMBL9525301 | 0.83 | KMT2A (0.41) | KMT2AMEN1PLA2G10PLA2G5 | |
| SCHEMBL10638447 | 0.79 | ALDH1A1 (0.39) | KMT2AMEN1PLA2G10PLA2G5 | |
| SCHEMBL10376676 | 0.79 | ALDH1A1 (0.39) | KMT2AMEN1PLA2G10PLA2G5 | |
| SCHEMBL10376315 | 0.79 | ALDH1A1 (0.39) | KMT2AMEN1PLA2G10PLA2G5 | |
| SCHEMBL10376336 | 0.78 | PLA2G10 (0.37) | KMT2AMEN1PLA2G10PLA2G5POLB | |
| SCHEMBL9526118 | 0.77 | ACE (0.43) | — | |
| SCHEMBL10378356 | 0.77 | PLA2G10 (0.35) | PLA2G10PLA2G5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365045-B1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1993-12-01 | — | — | EP | disclosed |
| EP-0365045-A1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1990-04-25 | — | — | EP | disclosed |
| US-4699905-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1987-10-13 | — | — | US | disclosed |
| EP-0161801-A2 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1985-11-21 | — | — | EP | disclosed |