Acetic Acid

Acetic Acid

SCHEMBL9526438

CC(=O)O.O=C(O)CCCCCCCCCCCCCC1=CC(O)c2ccccc21

nearest known ligand 0.46

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 2/20 0.46
MAPT P10636 1/20 0.46
KMT2A Q03164 1/20 0.41
HDAC3 O15379 2/20 0.40
HDAC4 P56524 2/20 0.40
HDAC1 Q13547 2/20 0.40
HDAC7 Q8WUI4 2/20 0.40
HDAC2 Q92769 2/20 0.40
HDAC10 Q969S8 2/20 0.40
HDAC11 Q96DB2 2/20 0.40
HDAC8 Q9BY41 2/20 0.40
HDAC6 Q9UBN7 2/20 0.40
HDAC9 Q9UKV0 2/20 0.40
HDAC5 Q9UQL6 2/20 0.40
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
PRNP P04156 1/20 0.39
RECQL P46063 1/20 0.39
SLC6A3 Q01959 2/20 0.39
HTR2C P28335 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17417245 0.96 MAPT (0.50) RXFP1MAPTKMT2AHDAC3HDAC4
SCHEMBL17221909 0.96 MAPT (0.50) RXFP1MAPTKMT2AHDAC3HDAC4
SCHEMBL6866716 0.96 MAPT (0.50) RXFP1MAPTKMT2AHDAC3HDAC4
SCHEMBL2463719 0.96 MAPT (0.50) RXFP1MAPTKMT2AHDAC3HDAC4
SCHEMBL2426303 0.84 KEAP1 (0.44) RXFP1MAPTHDAC3HDAC4HDAC1
SCHEMBL458928 0.70 SLC22A12 (0.39) MAPTKMT2A
SCHEMBL616045 0.70 SLC22A12 (0.39) MAPTKMT2A
SCHEMBL9960738 0.70 POLB (0.35) MAPTKMT2AALDH1A1RECQL
SCHEMBL9960857 0.68 ALDH1A1 (0.39) ALDH1A1MAPK1EGFR
Myristic Acid SCHEMBL29234157 0.67 GPR84 (0.45) MAPTKMT2AHDAC11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0553107-A1 PROTEIN KINASE C MODULATORS WITH ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY PROCYON PHARMACEUTICALS, INC. (US) 1993-08-04 EP disclosed