Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656317 | 0.79 | SMN1; SMN2 (0.60) | MAPTTDP1LMNAGAASMN1; SMN2 | |
| SCHEMBL407605 | 0.78 | KMO (0.67) | KMOPRSS1PRSS2PRSS3HDAC8 | |
| SCHEMBL19608630 | 0.78 | PRSS1 (0.64) | KMOPRSS1PRSS2PRSS3HDAC8 | |
| SCHEMBL13754825 | 0.78 | PRSS1 (0.64) | KMOPRSS1PRSS2PRSS3HDAC8 | |
| SCHEMBL2135450 | 0.78 | KMO (0.55) | KMOPRSS1PRSS2PRSS3HDAC8 | |
| SCHEMBL29446517 | 0.78 | KMO (0.67) | KMOPRSS1PRSS2PRSS3HDAC8 | |
| SCHEMBL608234 | 0.78 | — | — | |
| SCHEMBL14108353 | 0.78 | KMO (0.50) | KMOPRSS1PRSS2PRSS3HDAC8 | |
| Acetic Acid SCHEMBL29287805 | 0.77 | KMO (0.84) | KMOHDAC8MAPTTDP1LMNA | |
| SCHEMBL16902385 | 0.77 | PRSS1 (0.62) | KMOPRSS1PRSS2PRSS3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550576-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |