Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526539 | 0.90 | AGTR2 (0.41) | AGTR2AGTR1SLC22A12 | |
| SCHEMBL9530005 | 0.85 | AGTR2 (0.40) | AGTR2 | |
| SCHEMBL9530652 | 0.78 | METAP2 (0.36) | METAP2 | |
| SCHEMBL9530304 | 0.74 | EDNRA (0.35) | AGTR2AGTR1PTGS1PTGS2 | |
| SCHEMBL9526538 | 0.73 | AGTR2 (0.39) | AGTR2AGTR1 | |
| SCHEMBL9526460 | 0.72 | AGTR2 (0.42) | AGTR2AGTR1SLC22A12PTGS1PTGS2 | |
| SCHEMBL9152794 | 0.71 | — | — | |
| SCHEMBL9526081 | 0.71 | AGTR2 (0.53) | AGTR2AGTR1 | |
| SCHEMBL9527244 | 0.70 | AGTR2 (0.46) | AGTR2AGTR1 | |
| SCHEMBL9530023 | 0.70 | AGTR1 (0.32) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523141-A4 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | — | 1993-04-21 | — | — | EP | disclosed |
| EP-0523141-A1 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | MERCK & CO. INC. (US) | 1993-01-20 | — | — | EP | disclosed |