Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B | P35368 | 8/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.55 |
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | BRD4 | O60885 | 5/20 | 0.48 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532108 | 0.93 | ADRA1B (0.55) | ADRA1BADRA1DADRA1AHTR1ABRD4 | |
| SCHEMBL9527346 | 0.87 | ADRA1A (0.65) | ADRA1BADRA1DADRA1AHTR1A | |
| SCHEMBL9527589 | 0.87 | ADRA1B (0.51) | ADRA1BADRA1DADRA1AHTR1A | |
| SCHEMBL9763125 | 0.87 | BRD4 (0.50) | ADRA1BADRA1DADRA1AHTR1ABRD4 | |
| SCHEMBL9528091 | 0.85 | BRD4 (0.45) | ADRA1BADRA1DADRA1AHTR1ABRD4 | |
| SCHEMBL9528552 | 0.85 | ADRA1B (0.60) | ADRA1BADRA1DADRA1AHTR1A | |
| SCHEMBL9527001 | 0.82 | ADRA1A (0.63) | ADRA1BADRA1DADRA1AHTR1A | |
| SCHEMBL9527333 | 0.82 | HTR1A (0.50) | ADRA1BADRA1DADRA1AHTR1A | |
| SCHEMBL9528829 | 0.81 | BRD4 (0.48) | ADRA1BADRA1DADRA1AHTR1ABRD4 | |
| SCHEMBL9527827 | 0.81 | HTR1A (0.60) | ADRA1BADRA1DADRA1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |