Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.61 |
| ▸ | DRD2 | P14416 | 7/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | HTR7 | P34969 | 3/20 | 0.61 |
| ▸ | HTR6 | P50406 | 3/20 | 0.61 |
| ▸ | DRD3 | P35462 | 3/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527917 | 0.91 | HTR1A (0.60) | HTR1ADRD2ADRA1AHTR2AHTR7 | |
| SCHEMBL9527778 | 0.83 | HTR1A (0.58) | HTR1ADRD2ADRA1AHTR2AHTR7 | |
| SCHEMBL8135869 | 0.81 | HTR1A (0.68) | HTR1ADRD2ADRA1AHTR2AHTR7 | |
| SCHEMBL9528269 | 0.80 | HTR1A (0.61) | HTR1ADRD2ADRA1AHTR2AHTR7 | |
| SCHEMBL9528063 | 0.80 | ADRA1A (0.77) | HTR1ADRD2ADRA1AHTR2AHTR7 | |
| SCHEMBL8130109 | 0.80 | DRD2 (0.64) | HTR1ADRD2ADRA1AHTR2AHTR7 | |
| SCHEMBL8130173 | 0.79 | DRD2 (0.71) | HTR1ADRD2ADRA1AHTR2AHTR7 | |
| SCHEMBL9526817 | 0.79 | ADRA1A (0.63) | HTR1ADRD2ADRA1AHTR2ADRD3 | |
| SCHEMBL9528449 | 0.78 | ADRA1A (0.65) | HTR1ADRD2ADRA1AHTR2AHTR7 | |
| SCHEMBL9527827 | 0.78 | HTR1A (0.60) | HTR1ADRD2ADRA1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |