Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527274 | 0.86 | BPTF (0.47) | ATMKMT2APOLBSIRT6MAPT | |
| SCHEMBL9528853 | 0.85 | KAT2B (0.60) | CNR1CNR2BRD4BRD9KAT2B | |
| SCHEMBL9531572 | 0.85 | KAT2B (0.58) | CNR1CNR2BRD4BRD9KAT2B | |
| SCHEMBL27263874 | 0.82 | ATM (0.47) | ATMKMT2AMAPTCA12CA1 | |
| SCHEMBL9527132 | 0.82 | KAT2B (0.49) | CNR1CNR2BRD4BRD9KAT2B | |
| SCHEMBL9527765 | 0.81 | KMT2A (0.53) | KMT2ABRD4BRD9KAT2BMAPT | |
| SCHEMBL9527777 | 0.80 | KAT2B (0.57) | BRD4BRD9KAT2BMAPTCA12 | |
| SCHEMBL9531536 | 0.77 | KCNH2 (0.53) | MAPTHTR1ALMNAHTR7 | |
| SCHEMBL9527544 | 0.77 | KAT2B (0.56) | CNR1CNR2BRD4BRD9KAT2B | |
| SCHEMBL9527047 | 0.76 | BRD4 (0.57) | BRD4BRD9KAT2BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |