Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527101 | 0.86 | ATM (0.47) | KMT2APOLBSIRT6LMNAMAPT | |
| SCHEMBL9529694 | 0.85 | DRD2 (0.54) | BPTFLMNAMAPTHTR1A | |
| SCHEMBL9527024 | 0.85 | BPTF (0.53) | BPTFKMT2APOLBHTR1AHTR7 | |
| SCHEMBL9529009 | 0.82 | BPTF (0.54) | BPTFHTR1AMAPK1 | |
| SCHEMBL9527290 | 0.81 | KCNH2 (0.51) | BPTFKMT2AMAPTMAPK1 | |
| SCHEMBL9531700 | 0.78 | BPTF (0.46) | BPTFKMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL27263874 | 0.78 | ATM (0.47) | KMT2ALMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9531418 | 0.77 | KCNH2 (0.53) | LMNAMAPTSMN1; SMN2ALDH1A1HTR1A | |
| SCHEMBL9527111 | 0.77 | BPTF (0.51) | BPTFPOLBALDH1A1HTR1AHTR7 | |
| SCHEMBL9531556 | 0.76 | ADRA1A (0.53) | BPTFHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |