Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 12/20 | 0.58 |
| ▸ | BRD4 | O60885 | 6/20 | 0.58 |
| ▸ | BRD9 | Q9H8M2 | 5/20 | 0.58 |
| ▸ | BPTF | Q12830 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527765 | 0.90 | KMT2A (0.53) | KAT2BBRD4BRD9BPTFSMN1; SMN2 | |
| SCHEMBL9528853 | 0.89 | KAT2B (0.60) | KAT2BBRD4BRD9BPTFCNR1 | |
| SCHEMBL9527132 | 0.87 | KAT2B (0.49) | KAT2BBRD4BRD9BPTFCNR1 | |
| SCHEMBL9531536 | 0.87 | KCNH2 (0.53) | BPTFKDM4ESMN1; SMN2ADRA1AADRA1B | |
| SCHEMBL9527047 | 0.86 | BRD4 (0.57) | KAT2BBRD4BRD9BPTFADRA1D | |
| SCHEMBL9527101 | 0.85 | ATM (0.47) | KAT2BBRD4BRD9CNR1CNR2 | |
| SCHEMBL9527623 | 0.85 | HTR7 (0.49) | BPTFADRA1ADRD2 | |
| SCHEMBL9531491 | 0.85 | BRD4 (0.51) | KAT2BBRD4BRD9BPTFADRA1D | |
| SCHEMBL9527005 | 0.85 | ADRA1A (0.52) | KAT2BBRD4BRD9BPTFKDM4E | |
| SCHEMBL9532001 | 0.85 | KAT2B (0.59) | KAT2BBRD4BRD9BPTFADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |