Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 7/20 | 0.60 |
| ▸ | BRD4 | O60885 | 6/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | BPTF | Q12830 | 2/20 | 0.54 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527777 | 0.94 | KAT2B (0.57) | KAT2BBRD4DRD2HTR2AHRH1 | |
| SCHEMBL9531572 | 0.89 | KAT2B (0.58) | KAT2BBRD4DRD2HTR2AHRH1 | |
| SCHEMBL9527101 | 0.85 | ATM (0.47) | KAT2BBRD4BRD9CNR1CNR2 | |
| SCHEMBL9527132 | 0.85 | KAT2B (0.49) | KAT2BBRD4BPTFBRD9CNR1 | |
| SCHEMBL9529694 | 0.85 | DRD2 (0.54) | KAT2BBRD4DRD2HTR2AHRH1 | |
| SCHEMBL9527765 | 0.84 | KMT2A (0.53) | KAT2BBRD4HRH1BPTFBRD9 | |
| SCHEMBL9527037 | 0.83 | DRD2 (0.49) | DRD2HTR2AHRH1 | |
| SCHEMBL9527005 | 0.83 | ADRA1A (0.52) | KAT2BBRD4DRD2HTR2AHRH1 | |
| SCHEMBL6181302 | 0.81 | DRD2 (0.55) | DRD2HTR2AHRH1TP53 | |
| SCHEMBL27264164 | 0.81 | BPTF (0.52) | KAT2BBRD4DRD2HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |