Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526203 | 0.80 | MYC (0.43) | ACHEPARP1PARP10PARP11TYR | |
| SCHEMBL9527164 | 0.80 | NOTUM (0.39) | ACHEPARP1PARP10PARP11TYR | |
| Hydrochloric Acid SCHEMBL9526664 | 0.79 | MYC (0.42) | ACHEPARP1PARP10PARP11TYR | |
| SCHEMBL9526658 | 0.79 | TYR (0.39) | ACHEPARP1PARP10PARP11TYR | |
| SCHEMBL12602209 | 0.77 | CA12 (0.44) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL9526252 | 0.69 | METAP1 (0.45) | GSK3BACHEPARP1PARP10HSD11B1 | |
| SCHEMBL5725592 | 0.68 | GSK3B (0.48) | GSK3BPTPN1LMNAALDH1A1GAA | |
| SCHEMBL7712845 | 0.68 | RXRA (0.43) | ACHEPARP1PARP10PARP11NOTUM | |
| SCHEMBL8931109 | 0.67 | SLC9A1 (0.33) | TYRLMNAMYCCA1CA2 | |
| SCHEMBL2052193 | 0.67 | ACHE (0.47) | ACHEPARP1PARP10PARP11TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310745-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | ORION-YHTYMÄ OY (FI) | 1993-01-27 | — | — | EP | disclosed |
| EP-0183492-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos-Yhtyma Oy (FI) | 1989-11-15 | — | — | EP | disclosed |
| EP-0310745-A2 | Substituted imidazole derivatives and their preparation and use | ORION-YHTYMÄ OY (FI) | 1989-04-12 | — | — | EP | disclosed |