Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527191 | 0.86 | CYP19A1 (0.52) | CYP19A1CYP11B1CYP11B2ALDH1A1TBXAS1 | |
| Hydrochloric Acid SCHEMBL9524018 | 0.83 | ALDH1A1 (0.47) | CYP19A1CYP11B1CYP11B2ALDH1A1TBXAS1 | |
| SCHEMBL9527175 | 0.81 | CYP19A1 (0.47) | CYP19A1CYP11B1CYP11B2ALDH1A1TBXAS1 | |
| Hydrochloric Acid SCHEMBL9523846 | 0.81 | ALDH1A1 (0.46) | CYP19A1CYP11B1CYP11B2ALDH1A1TBXAS1 | |
| SCHEMBL9868315 | 0.80 | CYP19A1 (0.46) | CYP19A1CYP11B1CYP11B2ALDH1A1TBXAS1 | |
| SCHEMBL9707231 | 0.80 | CYP11B1 (0.51) | CYP19A1CYP11B1CYP11B2ALDH1A1TBXAS1 | |
| Hydrochloric Acid SCHEMBL9525196 | 0.80 | LMNA (0.48) | CYP19A1CYP11B1CYP11B2ALDH1A1TBXAS1 | |
| SCHEMBL9525445 | 0.79 | CYP11B1 (0.51) | CYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL9524363 | 0.79 | CYP19A1 (0.52) | CYP19A1CYP11B1CYP11B2ALDH1A1TBXAS1 | |
| SCHEMBL9527445 | 0.77 | CYP11B1 (0.61) | CYP19A1CYP11B1CYP11B2TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |