Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 2/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524840 | 0.83 | CDC7 (0.36) | PDE4APDE4BPDE4CPDE4DMAP3K5 | |
| SCHEMBL9525175 | 0.80 | NPC1 (0.36) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8332841 | 0.78 | METAP2 (0.40) | — | |
| SCHEMBL9527814 | 0.78 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| Hydrochloric Acid SCHEMBL9627192 | 0.77 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9524863 | 0.74 | CLK4 (0.40) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8195282 | 0.74 | OPRD1 (0.44) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9524497 | 0.73 | GRM5 (0.39) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9524349 | 0.73 | CCR1 (0.37) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9524637 | 0.72 | GRM5 (0.39) | PDE4APDE4BPDE4CPDE4DABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | claimed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |