Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.57 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.57 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MDH2 | P40926 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20610077 | 0.83 | LTA4H (0.62) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| Hydrochloric Acid SCHEMBL20610072 | 0.83 | LTA4H (0.62) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| Hydrochloric Acid SCHEMBL20610074 | 0.83 | LTA4H (0.62) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL17520563 | 0.80 | LTA4H (0.56) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL20634174 | 0.79 | TRPM8 (0.57) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| Hydrochloric Acid SCHEMBL17500243 | 0.79 | LTA4H (0.55) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL20634163 | 0.79 | TRPM8 (0.57) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL20634172 | 0.79 | TRPM8 (0.57) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL20610249 | 0.78 | LTA4H (0.56) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL20610235 | 0.78 | LTA4H (0.56) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548250-A4 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0548250-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY. | RHONE POULENC RORER INT (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004321-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-03-19 | — | — | WO | disclosed |