Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7065492 | 0.82 | PDGFRB (0.73) | PDGFRBPDGFRAMEN1KMT2ANPC1 | |
| SCHEMBL9529663 | 0.79 | PDE10A (0.51) | GPBAR1CYSLTR1PDE10ACYSLTR2 | |
| SCHEMBL7599570 | 0.77 | GPBAR1 (0.82) | GPBAR1CYSLTR1PDE10ACYSLTR2 | |
| SCHEMBL7801672 | 0.76 | GPBAR1 (0.85) | GPBAR1CYSLTR1PDE10ACYSLTR2 | |
| SCHEMBL10690965 | 0.75 | CYSLTR1 (0.76) | GPBAR1CYSLTR1PDE10ACYSLTR2 | |
| SCHEMBL9129064 | 0.75 | GPBAR1 (0.82) | GPBAR1CYSLTR1PDE10ACYSLTR2 | |
| SCHEMBL9201947 | 0.74 | GPBAR1 (0.54) | GPBAR1CYSLTR1CYP3A4CYP2C9 | |
| SCHEMBL7801642 | 0.74 | GPBAR1 (0.81) | GPBAR1CYSLTR1 | |
| SCHEMBL6389802 | 0.74 | FLT3 (0.80) | PDGFRBPDGFRAMEN1KMT2ANPC1 | |
| SCHEMBL6168456 | 0.73 | MEN1 (0.70) | PDGFRBPDGFRAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |