Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 4/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | MATK | P42679 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896271 | 0.84 | LMNA (0.40) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL9331958 | 0.82 | L3MBTL1 (0.53) | L3MBTL1LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL23752482 | 0.79 | NPC1 (0.53) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL10000033 | 0.79 | LMNA (0.53) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL416380 | 0.77 | NPC1 (0.44) | MAPK14GCGRKDM4EALDH1A1NPC1 | |
| SCHEMBL420012 | 0.74 | MGAM (0.43) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL16896257 | 0.73 | BTK (0.44) | LMNAMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL6410220 | 0.71 | MAPK14 (0.55) | MAPK14L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL14392319 | 0.71 | BRAF (0.41) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL12877465 | 0.71 | TGFBR1 (0.42) | MAPK13MAPK12MAPK11MAPK14MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276793-B1 | 3-ARYL-5-ALKYLTHIO-4H-1,2,4-TRIAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-16 | — | — | EP | disclosed |