Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15013285 | 0.90 | MAPT (0.55) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL2305236 | 0.87 | NPC1 (0.68) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL30015078 | 0.87 | NPC1 (0.68) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL29617906 | 0.83 | HPD (0.52) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL30318898 | 0.83 | HPD (0.49) | HTR1AADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL15536327 | 0.83 | PIN1 (0.50) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL647866 | 0.83 | TDP1 (0.56) | HTR1AADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL2892659 | 0.83 | HPD (0.52) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL29617955 | 0.83 | MAPT (0.47) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL1121791 | 0.83 | HPD (0.49) | HTR1AADRA1DADRA1AADRA1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266326-B1 | NOVEL DERIVATIVES OF BENZIMIDAZOLES ACTIVE AS ANTI-ULCER AGENTS | Aktiebolaget Hässle (SE) | 1993-03-10 | — | — | EP | disclosed |
| US-5106862-A | DERIVATIVES OF BENZIMIDAZOLES ACTIVE AS ANTI-ULCER AGENTS | AKTIEBOLAGET HASSLE (SE) | 1992-04-21 | — | — | US | disclosed |
| US-4925853-A | Antiinflammatory, antiallergens, antiulcer agents | BEECHAM GROUP PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0266326-A1 | Novel derivatives of benzimidazoles active as anti-ulcer agents | Aktiebolaget Hässle (SE) | 1988-05-04 | — | — | EP | disclosed |
| EP-0178413-A1 | Benzimidazoles | BEECHAM GROUP PLC (GB) | 1986-04-23 | — | — | EP | disclosed |