Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 11/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 11/20 | 0.51 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004745 | 0.91 | AGTR1 (0.63) | AGTR1AGTR2PPARG | |
| SCHEMBL6004742 | 0.88 | AGTR1 (0.63) | AGTR1AGTR2 | |
| SCHEMBL6004915 | 0.84 | AGTR1 (0.55) | AGTR1AGTR2PPARG | |
| SCHEMBL9741307 | 0.83 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL6005938 | 0.81 | AGTR1 (0.50) | AGTR1AGTR2 | |
| SCHEMBL9738591 | 0.81 | AGTR1 (0.54) | AGTR1AGTR2 | |
| SCHEMBL9698178 | 0.80 | AGTR1 (0.44) | AGTR1AGTR2PPARG | |
| SCHEMBL6006020 | 0.79 | AGTR1 (0.61) | AGTR1AGTR2PPARG | |
| SCHEMBL8105315 | 0.79 | AGTR1 (0.59) | AGTR1AGTR2 | |
| SCHEMBL9552403 | 0.79 | LTB4R2 (0.51) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527851-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-02-24 | — | — | EP | disclosed |
| WO-1991017148-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-11-14 | — | — | WO | disclosed |