Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL952625 | 0.84 | MAP3K5 (0.43) | MAP3K5 | |
| SCHEMBL19878461 | 0.81 | MKNK1 (0.47) | MKNK1MKNK2MAP4K4ACVR1SYK | |
| SCHEMBL3086682 | 0.77 | MAP3K5 (0.52) | LMNAGAACLK1SMN1; SMN2MAP3K5 | |
| SCHEMBL31145789 | 0.76 | MAP3K8 (0.49) | MKNK1MKNK2MAPK1METAP2MAP4K4 | |
| SCHEMBL30792113 | 0.74 | BAZ2B (0.47) | CLK1SMN1; SMN2MAPK1MAP3K5SCN9A | |
| SCHEMBL30792141 | 0.74 | TGFBR1 (0.38) | MKNK1MKNK2MAPK1SCN9ATGFBR1 | |
| SCHEMBL956896 | 0.72 | LMNA (0.65) | LMNAGAACLK1SMN1; SMN2MAP3K5 | |
| SCHEMBL32686463 | 0.72 | CBL (0.46) | — | |
| SCHEMBL231896 | 0.71 | MKNK1 (0.56) | MKNK1MKNK2HCRTR1HCRTR2 | |
| SCHEMBL22368582 | 0.71 | LMNA (0.61) | LMNAGAACLK1SMN1; SMN2MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | claimed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | claimed |