SCHEMBL9529026

SCHEMBL9529026

c1ccc(C(=NOCc2ccccn2)c2ccncc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.57
SMN1; SMN2 Q16637 3/20 0.57
CYP1A2 P05177 1/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C9 P11712 1/20 0.57
HPGD P15428 1/20 0.57
CYP2C19 P33261 1/20 0.57
KMT2A Q03164 4/20 0.44
POLB P06746 2/20 0.44
TBXA2R P21731 8/20 0.43
NPSR1 Q6W5P4 1/20 0.43
MAPT P10636 1/20 0.42
MAPK1 P28482 1/20 0.42
TBXAS1 P24557 2/20 0.41
NPC1 O15118 1/20 0.40
LMNA P02545 1/20 0.40
RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10406925 0.87 TBXAS1 (0.51) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL9529568 0.85 KDM4E (0.51) ALDH1A1HPGDKMT2ATBXA2RMAPT
SCHEMBL10407005 0.81 ALDH1A1 (0.63) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL6600996 0.76 TBXA2R (0.36) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL9528177 0.75 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL9528119 0.75 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL10406690 0.75 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL9527590 0.75 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL15865998 0.74 SMN1; SMN2 (0.46) ALDH1A1SMN1; SMN2CYP1A2NPC1LMNA
SCHEMBL9530809 0.73 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0366006-B1 PYRIDYLKETOXIME ETHER COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING IT KAKEN PHARMACEUTICAL CO., LTD. (JP) 1993-09-29 EP disclosed
US-4971985-A ANTIISCHEMIC AGENTS, CARDIOVASCULAR DISORDERS KAKEN PHARMACEUTICAL CO., LTD. (JP) 1990-11-20 US disclosed
EP-0366006-A1 Pyridylketoxime ether compound and pharmaceutical composition containing it KAKEN PHARMACEUTICAL CO., LTD. (JP) 1990-05-02 EP disclosed