Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 7/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531083 | 0.85 | PDE10A (0.43) | PDE10AALOX5APCYSLTR1CYSLTR2 | |
| SCHEMBL9529663 | 0.79 | PDE10A (0.51) | PDE10AALOX5APCYSLTR1CYSLTR2FFAR1 | |
| SCHEMBL9210251 | 0.74 | ALOX5AP (0.55) | PDE10AALOX5APCYSLTR1ALOX5PTGS1 | |
| SCHEMBL2107856 | 0.74 | ALOX5AP (0.60) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL10690965 | 0.73 | CYSLTR1 (0.76) | PDE10AALOX5APCYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL4604394 | 0.73 | ALOX5AP (0.56) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL9212984 | 0.73 | ALOX5AP (0.51) | ALOX5APCYSLTR1ALOX5PTGS1PTGS2 | |
| SCHEMBL9530467 | 0.72 | ALOX5AP (0.44) | PDE10AALOX5APCYSLTR1CYSLTR2FFAR1 | |
| SCHEMBL8799860 | 0.72 | PDE10A (0.60) | PDE10ACYSLTR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL9201587 | 0.71 | CYSLTR1 (0.56) | PDE10ACYSLTR1CYSLTR2ALOX5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |