Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529663 | 0.80 | PDE10A (0.51) | ALOX5APPDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6992585 | 0.74 | RHEB (0.53) | MAPTRHEB | |
| SCHEMBL9203751 | 0.73 | ALOX5AP (0.49) | ALOX5APPDE10ALMNAMAPTHTT | |
| SCHEMBL9529057 | 0.72 | PDE10A (0.48) | ALOX5APPDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL1004347 | 0.72 | CYSLTR1 (0.61) | PDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9210004 | 0.72 | CYSLTR1 (0.51) | PDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL17663970 | 0.70 | PTK2 (0.48) | LMNAMAPTHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL10690965 | 0.69 | CYSLTR1 (0.76) | ALOX5APPDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL10662425 | 0.69 | CYSLTR1 (0.61) | PDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8690875 | 0.69 | LMNA (0.41) | PDE10ALMNASMN1; SMN2CYSLTR1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |