Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 9/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005873 | 0.88 | AGTR1 (0.55) | PPARGAGTR1AGTR2 | |
| SCHEMBL9737230 | 0.87 | FOLH1 (0.44) | FOLH1AGTR1AGTR2 | |
| SCHEMBL9552386 | 0.85 | FOLH1 (0.45) | FOLH1PPARGAGTR1AGTR2 | |
| SCHEMBL9530302 | 0.85 | AGTR1 (0.47) | FOLH1AGTR1AGTR2 | |
| SCHEMBL9528694 | 0.83 | FOLH1 (0.44) | FOLH1PPARGAGTR1AGTR2 | |
| SCHEMBL9527916 | 0.82 | AGTR1 (0.53) | FOLH1AGTR1AGTR2 | |
| SCHEMBL9735863 | 0.81 | FOLH1 (0.39) | FOLH1AGTR1AGTR2 | |
| SCHEMBL6006905 | 0.80 | PPARG (0.61) | PPARGAGTR1AGTR2 | |
| SCHEMBL6008225 | 0.79 | AGTR1 (0.69) | AGTR1AGTR2 | |
| SCHEMBL6007367 | 0.78 | AGTR1 (0.69) | PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527851-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-02-24 | — | — | EP | disclosed |
| WO-1991017148-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-11-14 | — | — | WO | disclosed |