Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.62 |
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.57 |
| ▸ | CYSLTR2 | Q9NS75 | 10/20 | 0.57 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530636 | 0.83 | GPBAR1 (0.62) | CYSLTR1GPBAR1 | |
| SCHEMBL852376 | 0.82 | TRPM8 (0.72) | MEN1KMT2ALTA4HPLA2G2ATRPM8 | |
| SCHEMBL9530835 | 0.81 | TRPM8 (0.61) | CYSLTR1CYSLTR2MEN1KMT2ALTA4H | |
| SCHEMBL9209634 | 0.81 | CYSLTR1 (0.59) | FFAR1AKR1B1CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8539274 | 0.80 | GPBAR1 (0.63) | FFAR1AKR1B1CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9656045 | 0.76 | CYSLTR1 (0.85) | FFAR1AKR1B1CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8649544 | 0.76 | FFAR1 (0.97) | FFAR1AKR1B1CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9209653 | 0.76 | GPBAR1 (0.53) | CYSLTR1CYSLTR2GPBAR1MEN1KMT2A | |
| SCHEMBL8690097 | 0.76 | CYP2C19 (0.61) | KMT2ATRPM8HTR1DKDM4E | |
| SCHEMBL9138220 | 0.74 | AKR1C2 (0.57) | FFAR1AKR1B1CYSLTR1CYSLTR2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |