Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.61 |
| ▸ | LTA4H | P09960 | 4/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529112 | 0.81 | FFAR1 (0.62) | TRPM8LTA4HPLA2G2AMEN1KMT2A | |
| SCHEMBL852640 | 0.77 | TRPM8 (0.66) | TRPM8LTA4HPLA2G2APOLBMTNR1A | |
| SCHEMBL9530636 | 0.77 | GPBAR1 (0.62) | CYSLTR1 | |
| SCHEMBL8802625 | 0.76 | FAAH (0.76) | TRPM8LTA4HPLA2G2AMEN1KMT2A | |
| SCHEMBL9202068 | 0.76 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2 | |
| SCHEMBL8539274 | 0.74 | GPBAR1 (0.63) | CYSLTR1CYSLTR2 | |
| SCHEMBL10550119 | 0.74 | TRPM8 (0.66) | TRPM8LTA4HPLA2G2AMTNR1AMTNR1B | |
| SCHEMBL8802846 | 0.73 | TRPM8 (0.68) | TRPM8KDM4EMAPT | |
| SCHEMBL9209634 | 0.73 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2 | |
| SCHEMBL5179389 | 0.72 | LTA4H (0.79) | TRPM8LTA4HPLA2G2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |