SCHEMBL9529565

SCHEMBL9529565

C=CCOc1cc(N=C=O)c(Cl)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPOX P50336 5/20 0.39
GAA P10253 2/20 0.38
TSHR P16473 2/20 0.38
HTR2C P28335 5/20 0.35
HTR2B P41595 4/20 0.35
HTR2A P28223 3/20 0.35
HSD17B10 Q99714 2/20 0.35
MAPK1 P28482 2/20 0.34
TDP1 Q9NUW8 1/20 0.34
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
HPGD P15428 2/20 0.32
ALDH1A1 P00352 1/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA9 Q16790 1/20 0.32
PDCD1 Q15116 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9533072 0.87 PPOX (0.43) PPOXGAATSHRHTR2CHTR2B
SCHEMBL9528156 0.81 MAPK1 (0.51) PPOXGAATSHRHTR2CHTR2B
SCHEMBL9835490 0.80 KDM4E (0.39) PPOXTSHRHTR2CHTR2AMAPK1
SCHEMBL10433969 0.78 MAPT (0.42) GAATSHRMAPK1TDP1NPC1
SCHEMBL5644779 0.78 TSHR (0.54) GAATSHRHTR2CHTR2BHTR2A
SCHEMBL9530684 0.77 LMNA (0.43) TSHRHTR2CHTR2BHTR2AMAPK1
SCHEMBL30826232 0.76 HTR2C (0.51) PPOXGAATSHRHTR2CHTR2B
SCHEMBL10399423 0.76 HTR2C (0.51) PPOXGAATSHRHTR2CHTR2B
SCHEMBL10980256 0.76 CYP3A4 (0.42) GAATSHRHSD17B10MAPK1TDP1
SCHEMBL12005486 0.75 LIG1 (0.41) GAATSHRHTR2CHTR2AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0371240-B1 USE OF N-PHENYL-SUBSTITUTED OXAZINDIONES AS HERBICIDES AND N-PHENYL-SUBSTITUTED OXAZINDIONES AND SOME PROCESSES FOR THEIR PRODUCTION BAYER AG (DE) 1993-06-16 EP disclosed
US-5164498-A Herbicidal N-phenyl-substituted oxazinediones BAYER AKTIENGESELLSCHAFT (DE) 1992-11-17 US disclosed
US-5061310-A HERBICIDAL N-PHENYL-SUBSTITUTED OXAZINEDIONES AND OXAZINONETHIONES BAYER AKTIENGESELLSCHAFT (DE) 1991-10-29 US disclosed
EP-0290902-A2 Condensed (thio)hydantoins BAYER AG (DE) 1988-11-17 EP disclosed